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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

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Follicle stimulating hormone (FSH) can increase at this time, and a recent study of postmenopausal women found that higher levels of FSH (which goes up during menopause in response to lower estrogen) were associated with increases in body fat

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